Article

Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription control

2019-05-20

Abstract excerpt

Cohesin is a ring-shaped multiprotein complex that is crucial for 3D genome organization and transcriptional regulation during differentiation and development. It also confers sister chromatid cohesion and facilitates DNA damage repair. Besides its core subunits SMC3, SMC1A and RAD21, cohesin contains in somatic cells one of two orthologous STAG subunits, SA1 or SA2. How these variable subunits affect the function...

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Literature Corpus work: 1cb413ce-51de-5b99-ac0e-36ef802c0f93
DOI: 10.1101/642959

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