Article

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities

2025-09-25

Abstract excerpt

Mutations in anaplastic lymphoma kinase (ALK) are associated with high-risk neuroblastoma, a childhood cancer arising in trunk neural crest cells. The role of ALK in undifferentiated NC is still unknown; however, the presence of activating mutations in ALK correlates with migratory and invasive cell behaviours in neuroblastoma cell lines. Here, we show the functional consequences of ALK overexpression on neural cr...

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Literature Corpus work: 75444a57-4692-5535-bb60-075194cb08b0
DOI: 10.1101/2025.09.25.677354

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