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Article

Oncogenic mutations of ALK kinase in neuroblastoma.

Nature - 16 Oct 2008

Chen Yuyan, Takita Junko, Choi Young Lim, Kato Motohiro, Ohira Miki, Sanada Masashi, Wang Lili, Soda Manabu, Kikuchi Akira, Igarashi Takashi, Nakagawara Akira, Hayashi Yasuhide, Mano Hiroyuki, Ogawa Seishi

Abstract excerpt

Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes, including a high frequency of MYCN amplification, loss of heterozygosity at 1p36 and 11q, and gain of genetic material from 17q, all of which have been implicated in the pathogenesis of neuroblastoma. However, the scarcity of reliable...

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Source

Identifiers

PMID: 18923524
DOI: 10.1038/nature07399

Genes

ALK
MYCN
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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