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Article

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice

4 Jul 2012

Abstract excerpt

Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10% of sporadic neuroblastomas. However, the role of mutated ALK in tumorigenesis remains elusive. We demonstrate that targeted expression of the most frequent and aggressive variant, ALK(F1174L), is tumorigenic in mice. Tumors resembled human neuroblastomas in morphology, metastasis pattern, gene expression, and the...

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PMID: 22764207
DOI: 10.1126/scitranslmed.3003967

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