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Targeting anaplastic lymphoma kinase in neuroblastoma

26 Feb 2019

Abstract excerpt

Over the last decade, anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase (RTK), has been identified as a fusion partner in a diverse variety of translocation events resulting in oncogenic signaling in many different cancer types. In tumors where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture regarding the role of ALK as an oncogenic driver is less clear. Neuroblastoma is a...

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PMID: 30803032
DOI: 10.1111/apm.12940

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