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Article

ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.

Oncogene - 25 Aug 2016

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z-I, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H

Abstract excerpt

Overexpression of MYCN is a hallmark of neuroblastoma (NB). ALK(R1275Q), an activating mutation of ALK (anaplastic lymphoma kinase), has been found in sporadic and familial NB patients. In this report, we demonstrated that ALK(R1275Q) knock-in, MYCN transgenic compound mice developed NB with complete penetrance. Transcriptome analysis revealed that ALK(R1275Q) globally downregulated the expression of...

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Source

Identifiers

PMID: 26829053
DOI: 10.1038/onc.2015.519

Genes

ALK
MYCN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.PMID 26829053Read ↗

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastomaSemantic proximity Read ↗

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic MiceSemantic proximity Read ↗

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted TreatmentSemantic proximity Read ↗

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.Semantic proximity Read ↗

ALK upregulates POSTN and WNT signaling to drive neuroblastomaSemantic proximity Read ↗

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.Semantic proximity Read ↗

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatmentSemantic proximity Read ↗

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.Semantic proximity Read ↗

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells.Semantic proximity Read ↗

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy.Semantic proximity Read ↗

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastomaSemantic proximity Read ↗

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activitiesSemantic proximity Read ↗

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