Article
Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy.
Cancer research - 1 Jan 2011
Martinsson Tommy, Eriksson Therese, Abrahamsson Jonas, Caren Helena, Hansson Magnus, Kogner Per, Kamaraj Sattu, Schönherr Christina, Weinmar Joel, Ruuth Kristina, Palmer Ruth H, Hallberg Bengt
Abstract excerpt
Mutations in the kinase domain of the ALK kinase have emerged recently as important players in the genetics of the childhood tumor neuroblastoma. Here, we report the appearance of a novel ALK mutation in neuroblastoma, correlating with aggressive tumor behavior. Analyses of genomic DNA from biopsy samples initially showed ALK sequence to be wild type. However, during disease progression, mutation of amino acid...
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