Article
Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.
Oncogene - 13 Dec 2012
Schönherr C, Ruuth K, Kamaraj S, Wang C-L, Yang H-L, Combaret V, Djos A, Martinsson T, Christensen J G, Palmer R H, Hallberg B
Abstract excerpt
Neuroblastoma is a neural crest-derived embryonal tumour of the postganglionic sympathetic nervous system and a disease with several different chromosomal gains and losses, which include MYCN-amplified neuroblastoma on chromosome 2, deletions of parts of the chromosomes 1p and 11q, gain of parts of 17q and triploidy. Recently, activating mutations of the ALK (Anaplastic Lymphoma Kinase) RTK (Receptor Tyrosine...
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