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Article

ALK upregulates POSTN and WNT signaling to drive neuroblastoma

1 Mar 2024

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor of childhood. While MYCN and mutant anaplastic lymphoma kinase ( ALK F1174L ) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear. Here, we used a human stem cell-based model of neuroblastoma. Mis-expression of ALK F1174L and MYCN resulted in shorter latency compared to MYCN alone. MYCN tumors resembled adrenergic, while...

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Identifiers

PMID: 38451815
DOI: 10.1016/j.celrep.2024.113927

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