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Article

Differential Impact of ALK Mutations in Neuroblastoma.

JCO precision oncology - 1 Jan 2021

O'Donohue Tara, Gulati Nitya, Mauguen Audrey, Kushner Brian H, Shukla Neerav, Rodriguez-Sanchez M I, Bouvier Nancy, Roberts Stephen, Basu Ellen, Cheung Nai-Kong, Modak Shakeel

Abstract excerpt

PURPOSE: The tyrosine kinase receptor anaplastic lymphoma kinase (ALK) can be abnormally activated in neuroblastoma, and somatic ALK mutations occur in 6%-10% of patients. The differential clinical impact of these mutations has not been clearly elucidated. METHODS: Data on patients with neuroblastoma harboring ALK mutations were retrospectively analyzed. ALK sequencing was performed by whole-genome sequencing,...

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Identifiers

PMID: 34250410
DOI: 10.1200/PO.20.00181
PMCID: PMC8232802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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