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Article

Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer

29 Oct 2021

Abstract excerpt

Neuroblastoma is a common extracranial solid tumour of childhood, responsible for 15% of cancer-related deaths in children. Prognoses vary from spontaneous remission to aggressive disease with extensive metastases, where treatment is challenging. Tumours are thought to arise from sympathoadrenal progenitor cells, which derive from an embryonic cell population called neural crest cells that give rise to diverse...

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PMID: 34769149
DOI: 10.3390/ijms222111718

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