Article

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

2017-03-13

Abstract excerpt

The immune system plays a major role in human health and disease, and understanding genetic causes of interindividual variability of immune responses is vital. We isolated monocytes from 134 genotyped individuals, stimulated the cells with three defined microbe-associated molecular patterns (LPS, MDP, and ppp-dsRNA), and profiled the transcriptome at three time points. After mapping expression quantitative trait l...

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Literature Corpus work: 03bc88c3-fdb8-50d3-bf65-7e955a076631
DOI: 10.1101/116376

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