Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.

Nature communications - 28 Apr 2026

Randolph Haley E, Aguirre-Gamboa Raúl, Brunet-Ratnasingham Elsa, Nakanishi Tomoko, Mu Zepeng, Locher Veronica, Ketter Ellen, Brandolino Cary, Larochelle Catherine, Prat Alexandre, Arbour Nathalie, Dumaine Anne, Finzi Andrés, Durand Madeleine, Richards J Brent, Kaufmann Daniel E, Barreiro Luis B

Abstract excerpt

Genome-wide association studies performed in COVID-19 patients have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and disease severity. However, the underlying cis-regulatory genetic factors contributing to heterogeneity in the response to SARS-CoV-2 infection and their impact on clinical phenotypes remain enigmatic. Here, we use single-cell RNA-sequencing to quantify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Hospitalization

Share to Leukocytes, Mononuclear

Share to Monocytes

Share to SARS-CoV-2

Share to Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42049757
DOI: 10.1038/s41467-026-72393-w
PMCID: PMC13328456

Genes

CD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.PMID 42049757Read ↗

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patientsSemantic proximity Read ↗

Environmental and genetic drivers of population differences in SARS-CoV-2 immune responsesSemantic proximity Read ↗

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19Semantic proximity Read ↗

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues.Semantic proximity Read ↗

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell typesSemantic proximity Read ↗

Human genetic variants associated with COVID-19 severity are enriched in immune and epithelium regulatory networksSemantic proximity Read ↗

Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severitySemantic proximity Read ↗

Host methylation predicts SARS-CoV-2 infection and clinical outcomeSemantic proximity Read ↗

Epigenome-wide DNA methylation profiling of healthy COVID-19 recoverees reveals a unique signature in circulating immune cellsSemantic proximity Read ↗

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionSemantic proximity Read ↗

Host methylation predicts SARS-CoV-2 infection and clinical outcomeSemantic proximity Read ↗

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.