Article

Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection

2020-12-21

Abstract excerpt

Humans vary in their susceptibility to infectious disease, partly due to variation in the immune response following infection. Here, we used single-cell RNA-sequencing to quantify genetic contributions to this variation in peripheral blood mononuclear cells, focusing specifically on the transcriptional response to influenza infection. We find that monocytes are the most responsive to influenza infection, but that...

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Literature Corpus work: 972e6c79-5ef4-598d-b867-ea02cc3e4e40
DOI: 10.1101/2020.12.21.423830

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