Article
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Nature communications - 16 Aug 2017
Kim-Hellmuth Sarah, Bechheim Matthias, Pütz Benno, Mohammadi Pejman, Nédélec Yohann, Giangreco Nicholas, Becker Jessica, Kaiser Vera, Fricker Nadine, Beier Esther, Boor Peter, Castel Stephane E, Nöthen Markus M, Barreiro Luis B, Pickrell Joseph K, Müller-Myhsok Bertram, Lappalainen Tuuli, Schumacher Johannes, Hornung Veit
Abstract excerpt
The immune system plays a major role in human health and disease, and understanding genetic causes of interindividual variability of immune responses is vital. Here, we isolate monocytes from 134 genotyped individuals, stimulate these cells with three defined microbe-associated molecular patterns (LPS, MDP, and 5'-ppp-dsRNA), and profile the transcriptomes at three time points. Mapping expression quantitative...
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