Article

Respiratory complex and tissue lineage drive mutational patterns in the tumor mitochondrial genome

2020-08-18

Abstract excerpt

Mitochondrial DNA (mtDNA) encodes essential protein subunits and translational machinery for four distinct complexes of oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data, we demonstrate that pathogenic mtDNA mutations arise in tumors at a rate comparable to the most common cancer driver genes. We identify OXPHOS complexes as critical determinants shaping somatic mtDNA mutation patter...

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Literature Corpus work: a12af3ca-c32c-5766-bf7f-0643f5aaf81d
DOI: 10.1101/2020.08.18.256362

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