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Article

The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products.

The EMBO journal - 15 Nov 1996

Sarnovsky R J, May E W, Craig N L

Abstract excerpt

The bacterial transposon Tn7 translocates by a cut and paste mechanism: excision from the donor site results from double-strand breaks at each end of Tn7 and target insertion results from joining of the exposed 3' Tn7 tips to the target DNA. Through site-directed mutagenesis of the Tn7-encoded transposition proteins TnsA and TnsB, we demonstrate that the Tn7 transposase is a heteromeric complex of these proteins,...

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Identifiers

PMID: 8947057
PMCID: PMC452457

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