Article

Genomic DNA transposition induced by human PGBD5

2015-08-03

Abstract excerpt

Transposons are mobile genetic elements that are found in nearly all organisms, including humans. Mobilization of DNA transposons by transposase enzymes can cause genomic rearrangements, but our knowledge of human genes derived from transposases is limited. Here, we find that the protein encoded by human PGBD5 , the most evolutionarily conserved transposable element-derived gene in chordates, can induce stereotyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1be2218c-3f53-50ca-8ae4-2b10e7010521
DOI: 10.1101/023887

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic DNA transposition induced by human PGBD5DOI 10.1101/023887Read

The <i>piggyBac</i> derived transposase 5 (PGBD5) can interact with human <i>piggyBac</i> -like elementsSemantic proximity Read

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumorsSemantic proximity Read

Forward genetic screen of human transposase genomic rearrangementsSemantic proximity Read

Forward genetic screen of human transposase genomic rearrangements.Semantic proximity Read

A transposase-derived gene required for human brain developmentSemantic proximity Read

Analysis of DNA transposition by DNA transposases in human cellsSemantic proximity Read

An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.Semantic proximity Read

Structure-based recasting of a mammalian DNA transpososome as an obligate heterodimerSemantic proximity Read

Transposable element-mediated rearrangements are prevalent in human genomesSemantic proximity Read

The role of transposable elements in human evolution and methods for their functional analysis: current status and future perspectives.Semantic proximity Read

<i>Pgbd5</i> impacts neuronal differentiation and double strand breaks signaling in the developing cortexSemantic proximity Read

Site-specific integration of transposon via engineered piggyBac transposaseSemantic proximity Read