Article

Dynamic extrinsic pacing of the <i>HOX</i> clock in human axial progenitors controls motor neuron subtype specification

2020-06-27

Abstract excerpt

<h4>SUMMARY</h4> Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether HOX genes sequential activation, the “ HOX clock”, is paced by intrinsic chromatin-based timing mechanisms or by temporal changes in extrinsic cues remains unclear. Here, we studied HOX clock pacing in human pluripotent stem c...

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Literature Corpus work: 74a51734-40b6-5b26-a74d-25776b6e52db
DOI: 10.1101/2020.06.27.175646

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