Article

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

2018-02-23

Abstract excerpt

<h4>SUMMARY</h4> Heterochrony, defined as differences in the timing of developmental processes, impacts organ development, homeostasis, and regeneration. The molecular basis of heterochrony in mammalian tissues is poorly understood. We report that Hedgehog signaling activates a heterochronic pathway that controls differentiation timing in multiple lineages. A differentiation trajectory from second heart field car...

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Literature Corpus work: ad0058df-2195-5da3-b42d-2ee7ce65cc9b
DOI: 10.1101/270751

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