Article
CRISPR screens identify gene targets at breast cancer risk loci.
Genome biology - 29 Mar 2023
Tuano Natasha K, Beesley Jonathan, Manning Murray, Shi Wei, Perlaza-Jimenez Laura, Malaver-Ortega Luis F, Paynter Jacob M, Black Debra, Civitarese Andrew, McCue Karen, Hatzipantelis Aaron, Hillman Kristine, Kaufmann Susanne, Sivakumaran Haran, Polo Jose M, Reddel Roger R, Band Vimla, French Juliet D, Edwards Stacey L, Powell David R, Chenevix-Trench Georgia, Rosenbluh Joseph
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk by regulating gene expression. However, pinpointing the exact target of the association, and identifying the phenotype it mediates, is a major challenge in the interpretation and translation of GWAS....
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