Article

Using long-read sequencing to detect imprinted DNA methylation

2018-10-17

Abstract excerpt

Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early development of humans and other mammals. Of particular interest are regions of differential methylation between parental alleles, as these often dictate monoallelic gene expression, resulting in parent of origin specific control of the embryonic transcriptome and subsequent development, in a phenomenon known as genomic...

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Literature Corpus work: 7459eeb0-77aa-53e7-9d23-e36a8980558c
DOI: 10.1101/445924

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