Article

Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq

2022-05-25

Abstract excerpt

Hundreds of loci in human genomes have alleles that are methylated differentially according to their parent of origin. These imprinted loci generally show little variation across tissues, individuals, and populations. We show that such loci can be used to distinguish the maternal and paternal homologs for all autosomes, without the need for the parental DNA. We integrate methylation-detecting nanopore sequencing w...

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Literature Corpus work: d9ec4d64-aa62-5e44-99e1-58008d85c1e1
DOI: 10.1101/2022.05.24.493320

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