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How genome-wide approaches can be used to unravel the remaining secrets of the imprintome

1 Jul 2010

Abstract excerpt

Genomic imprinting is the differential expression of genes according to their transmitting parent and is achieved by labelling of the two alleles with different epigenetic marks. The majority of described imprinted genes are present in clusters with coordinate regulation. Multiple mechanisms are known to regulate this differential expression, including repression of one allele by the action of cis-acting macro...

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PMID: 20675687
DOI: 10.1093/bfgp/elq018

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