Article
Next generation sequencing in epigenetics: insights and challenges.
Seminars in cell & developmental biology - 1 Apr 2012
Meaburn Emma, Schulz Reiner
Abstract excerpt
The epigenetics community was an early adopter of next generation sequencing (NGS). NGS-based studies have provided detailed and comprehensive views of epigenetic modifications for the genomes of many species and cell types. Recently, DNA methylation has attracted much attention due to the discovery of 5-hydroxymethyl-cytosine and its role in epigenetic reprogramming and pluripotency. This renewed interest has...
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