Article
Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome.
Nature communications - 29 Jul 2026
Sigurpalsdottir Brynja, Holley Guillaume, Sverrisson Sverrir Þ, Magnusdottir Droplaug N, Olafsson Pall I, Gylfason Arnaldur, Magnusson Olafur Þ, Masson Gisli, Stefansson Olafur A, Halldorsson Bjarni V
Abstract excerpt
Aging is accompanied by widespread DNA methylation changes, yet their full genomic scope and parent-of-origin dynamics remain poorly understood. Here, we apply nanopore long-read sequencing to 7,284 whole blood samples enabling methylation measurements of 17,959,684 high-quality CpG units. Over 20% of the measured high quality CpG units undergo age-associated changes, predominantly hypomethylation. From these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.