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Article

Genomic landscape of human allele-specific DNA methylation.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

Fang Fang, Hodges Emily, Molaro Antoine, Dean Matthew, Hannon Gregory J, Smith Andrew D

Abstract excerpt

DNA methylation mediates imprinted gene expression by passing an epigenomic state across generations and differentially marking specific regulatory regions on maternal and paternal alleles. Imprinting has been tied to the evolution of the placenta in mammals and defects of imprinting have been associated with human diseases. Although recent advances in genome sequencing have revolutionized the study of DNA...

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Algorithms
Chromosomes, Human, X
CpG Islands
DNA Methylation
Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Imprinting

Induced Pluripotent Stem Cells

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Identifiers

PMID: 22523239
DOI: 10.1073/pnas.1201310109
PMCID: PMC3358917

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