Article
Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing.
eLife - 5 Jul 2022
Akbari Vahid, Garant Jean-Michel, O'Neill Kieran, Pandoh Pawan, Moore Richard, Marra Marco A, Hirst Martin, Jones Steven J M
Abstract excerpt
Imprinting is a critical part of normal embryonic development in mammals, controlled by defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting control regions. Direct nanopore sequencing of DNA provides a means to detect allelic methylation and to overcome the drawbacks of methylation array and short-read technologies. Here, we used publicly available nanopore sequencing data...
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