Article

Identification of an age-related Parkinson's disease risk factor that regulates sulfur metabolism

2021-12-22

Abstract excerpt

<title>Abstract</title> <p>Human aging is the main risk factor for Parkinson’s disease (PD). To better understand age-related PD pathogenesis, we modeled PD with directly reprogrammed dopaminergic neurons (iDA) which preserve donor aging signatures. By transcriptome analysis and immunohistochemistry on postmortem tissues, we identified a sulfurtransferase, TSTD1, to be upregulated in aged and diseased individuals...

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Literature Corpus work: 7457c1f6-3af8-5efb-96c5-51288c4971f5
DOI: 10.21203/rs.3.rs-1168396/v1

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