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Article

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation.

Cell reports - 18 Oct 2016

Vera Elsa, Bosco Nazario, Studer Lorenz

Abstract excerpt

Modeling late-onset disorders such as Parkinson's disease (PD) using iPSC technology remains a challenge, as current differentiation protocols yield cells with the properties of fetal-stage cells. Here, we tested whether it is possible to accelerate aging in vitro to trigger late-onset disease phenotypes in an iPSC model of PD. In order to manipulate a factor that is involved in natural aging as well as in...

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Identifiers

PMID: 27760320
DOI: 10.1016/j.celrep.2016.09.062
PMCID: PMC5089807

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