Article

Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila

2026-02-16

Abstract excerpt

<title>Abstract</title> <p> Polyamine homeostasis is tightly regulated by interconversion and catabolic pathways and has been increasingly implicated in neurodegenerative disorders, including Parkinson’s disease (PD), where accumulation of α-synuclein (α-Syn) perturbs neuronal homeostasis. Spermidine/spermine N¹-acetyltransferase 1 (SAT1) occupies a central position in polyamine interconversion, and alterations...

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Literature Corpus work: fa5d0699-561f-5c2c-9d14-6540c05633d3
DOI: 10.21203/rs.3.rs-8780765/v1

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