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Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease

4 Apr 2025

Abstract excerpt

BACKGROUND: Parkinson's disease (PD), a globally prevalent neurodegenerative disorder, has been implicated with oxidative stress (OS) as a central pathomechanism. Excessive reactive oxygen species (ROS) trigger neuronal damage and may induce disulfidptosis-a novel cell death modality not yet characterized in PD pathogenesis. METHOD: Integrated bioinformatics analyses were conducted using GEO datasets to identify...

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PMID: 40186271
DOI: 10.1186/s13041-025-01200-2

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