Article

The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons

2019-10-10

Abstract excerpt

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in huntingtin ( HTT ). While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the aging brain and is a feature of HD. We sought to interrogate the roles and interaction of age and oxidative stress in HD using primary Hu97/18 mouse neurons, neurons...

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Literature Corpus work: 382dcab7-7e02-5c3f-8d74-abeeeb5b36bc
DOI: 10.1101/800268

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