Article

Impaired striatal glutathione metabolism induces dopamine increase and motor dysfunction.

2023-01-10

Abstract excerpt

<title>Abstract</title> <p>Identification of initial triggering events in neurodegenerative disorders is critical to the development of preventive therapies. In Huntington’s disease (HD), hyperdopaminergia triggered by dysfunction of inhibitory indirect pathway spiny projection neurons (iSPNs) is believed to induce hyperkinesia, an early-stage HD symptom. Loss of TrkB signalling in iSPNs results in spontaneous mo...

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Literature Corpus work: 8b77dbc1-9bf5-5b11-ac1d-edf522c4d52d
DOI: 10.21203/rs.3.rs-2456799/v1

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