Article
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Cell death and differentiation - 1 Apr 2017
Celardo Ivana, Lehmann Susann, Costa Ana C, Loh Samantha Hy, Miguel Martins L
Abstract excerpt
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1 and parkin mutants, mitochondrial defects lead to the compensatory upregulation of the mitochondrial one-carbon cycle metabolism genes by an unknown mechanism. Here we uncover that this...
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