Article

Comparative Proteomic Analysis of Environmental and Genetic Models of Parkinson’s Disease Highlights the Role of Purine Metabolism

2026-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s Disease (PD) is the second most common neurodegenerative disease, with many cases being attributed to environmental contaminant exposures. Paraquat (PQ), is a pesticide and environmental neurotoxicant that has been strongly associated with increased risk of PD. PQ is known to be a weak inhibitor of complex I of the electron transport chain, and while its acute toxicity is well unders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d146431d-e637-5d3d-bd5e-d63c409ba4c0
DOI: 10.64898/2026.02.02.703282

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative Proteomic Analysis of Environmental and Genetic Models of Parkinson’s Disease Highlights the Role of Purine MetabolismDOI 10.64898/2026.02.02.703282Read

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological RelevanceSemantic proximity Read

Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s DiseaseSemantic proximity Read

Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in <i>Drosophila</i>Semantic proximity Read

Using ‘omics’ to define pathogenesis and biomarkers of Parkinson’s diseaseSemantic proximity Read

Disease-Toxicant Interactions in Parkinson's Disease Neuropathology.Semantic proximity Read

Exposure to rotenone triggers redox driven system-wide lipidome alterations and metabolic trade-offs linked to Parkinson’s diseaseSemantic proximity Read

Omics data integration suggests a potential idiopathic Parkinson’s disease signatureSemantic proximity Read

Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategiesSemantic proximity Read

Molecular Pathogenesis of Parkinson DiseaseSemantic proximity Read

Micro-/nano-plastics accentuate Parkinson’s Disease-relevant phenotypes in a <i>Drosophila</i> modelSemantic proximity Read

Mechanistic approaches to Parkinson's disease pathogenesis.Semantic proximity Read

Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.Semantic proximity Read