Article

ASS1 deficiency promotes ferroptosis vulnerability in dopaminergic neurons in Parkinson’s disease

2026-05-27

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. However, the metabolic mechanisms linking neuronal vulnerability to ferroptosis remain poorly understood. To address this question, we integrated single-nucleus and bulk RNA sequencing datasets from human substantia nigra to characterize cell-type-specific transcription...

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Literature Corpus work: e752ce24-cdb7-5b7c-90b4-495f6a24de26
DOI: 10.21203/rs.3.rs-9722320/v1

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