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Article

The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease

20 Aug 2021

Abstract excerpt

Mitochondrial dysfunction is one of the crucial factors involved in PD's pathogenicity, which emerges from a combination of genetic and environmental factors. These factors cause differential molecular expression in neurons, such as varied transcriptional regulation of genes, elevated oxidative stress, α-synuclein aggregation and endogenous neurotoxins release, which induces epigenetic modifications and triggers...

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PMID: 34414627
DOI: 10.1111/bpa.13012

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