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Article

Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016

Fischer Jared M, Calabrese Peter P, Miller Ashleigh J, Muñoz Nina M, Grady William M, Shibata Darryl, Liskay R Michael

Abstract excerpt

Intestinal stem cells (ISCs) are maintained by a niche mechanism, in which multiple ISCs undergo differential fates where a single ISC clone ultimately occupies the niche. Importantly, mutations continually accumulate within ISCs creating a potential competitive niche environment. Here we use single cell lineage tracing following stochastic transforming growth factor β receptor 2 (TgfβR2) mutation to show cell...

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Identifiers

PMID: 27791005
DOI: 10.1073/pnas.1611980113
PMCID: PMC5087053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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