Mutation, clonal fitness and field change in epithelial carcinogenesis.

doi:10.1002/path.4409

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Article

Mutation, clonal fitness and field change in epithelial carcinogenesis.

The Journal of pathology - 1 Nov 2014

Frede Julia, Adams David J, Jones Philip H

Abstract excerpt

Developments in lineage tracing in mouse models have revealed how stem cells maintain normal squamous and glandular epithelia. Here we review recent quantitative studies tracing the fate of individual mutant stem cells which have uncovered how common oncogenic mutations alter cell behaviour, creating clones with a growth advantage that may persist long term. In the intestine this occurs by a mutant clone...

Topics

Animals
Carcinogenesis
Clone Cells
Epithelium
Mutation
Neoplasms, Glandular and Epithelial
Neoplastic Stem Cells

Source

Open in PubMed

Identifiers

PMID: 25046364
DOI: 10.1002/path.4409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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