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Article

Tracing oncogene-driven remodelling of the intestinal stem cell niche.

Nature - 1 Jun 2021

Yum Min Kyu, Han Seungmin, Fink Juergen, Wu Szu-Hsien Sam, Dabrowska Catherine, Trendafilova Teodora, Mustata Roxana, Chatzeli Lemonia, Azzarelli Roberta, Pshenichnaya Irina, Lee Eunmin, England Frances, Kim Jong Kyoung, Stange Daniel E, Philpott Anna, Lee Joo-Hyeon, Koo Bon-Kyoung, Simons Benjamin D

Abstract excerpt

Interactions between tumour cells and the surrounding microenvironment contribute to tumour progression, metastasis and recurrence1-3. Although mosaic analyses in Drosophila have advanced our understanding of such interactions4,5, it has been difficult to engineer parallel approaches in vertebrates. Here we present an oncogene-associated, multicolour reporter mouse model-the Red2Onco system-that allows...

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Identifiers

PMID: 34079126
DOI: 10.1038/s41586-021-03605-0
PMCID: PMC7614896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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