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Article

Colon Stem Cell and Crypt Dynamics Exposed by Cell Lineage Reconstruction

28 Jul 2011

Abstract excerpt

Stem cell dynamics in vivo are often being studied by lineage tracing methods. Our laboratory has previously developed a retrospective method for reconstructing cell lineage trees from somatic mutations accumulated in microsatellites. This method was applied here to explore different aspects of stem cell dynamics in the mouse colon without the use of stem cell markers. We first demonstrated the reliability of our...

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PMID: 21829376
DOI: 10.1371/journal.pgen.1002192

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