Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.

doi:10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO;2-I

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.

The Journal of pathology - 1 Jan 1999

Garcia S B, Park H S, Novelli M, Wright N A

Abstract excerpt

There has been considerable debate about the origin of human tumours, whether they arise from a single cell and are clonal populations or whether there needs to be some sort of co-operativity between cells for the neoplastic process to begin. Current theories subscribe to the clonal view, where a series of mutations in one cell begins a process of selection and clonal evolution leading to the development of the...

Topics

Animals
Epithelium
Gastrointestinal Neoplasms
Humans
Mice
Mutation
Neoplastic Stem Cells
Precancerous Conditions

Source

Open in PubMed

Identifiers

PMID: 10341707
DOI: 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO;2-I

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics