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Article

Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.

The Journal of pathology - 1 Jan 1999

Garcia S B, Park H S, Novelli M, Wright N A

Abstract excerpt

There has been considerable debate about the origin of human tumours, whether they arise from a single cell and are clonal populations or whether there needs to be some sort of co-operativity between cells for the neoplastic process to begin. Current theories subscribe to the clonal view, where a series of mutations in one cell begins a process of selection and clonal evolution leading to the development of the...

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Identifiers

PMID: 10341707
DOI: 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO;2-I

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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