Article
TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.
Cell death and differentiation - 1 Oct 2017
Cammareri Patrizia, Vincent David F, Hodder Michael C, Ridgway Rachel A, Murgia Claudio, Nobis Max, Campbell Andrew D, Varga Julia, Huels David J, Subramani Chithra, Prescott Katie L H, Nixon Colin, Hedley Ann, Barry Simon T, Greten Florian R, Inman Gareth J, Sansom Owen J
Abstract excerpt
Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous work has shown that activating mutations of Kras or the NF-κB pathway can drive dedifferentiation of intestinal cells lacking Apc. To investigate this process...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.