Article

Regulatory logic of human cortex evolution by combinatorial perturbations

2025-05-01

Abstract excerpt

Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in scaffolding modern traits. Through multi-layered integration we selected 15 genes carrying nearly fixed sapiens -specific protein-coding mutations and developed a scalable design of combinatorial CRISPR-Cas9 bidirection...

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Literature Corpus work: 741d07bc-6321-5283-9166-6c4fb1136f7d
DOI: 10.1101/2025.04.28.651083

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