Article

Inferring and perturbing cell fate regulomes in human cerebral organoids

2021-08-24

Abstract excerpt

Self-organizing cerebral organoids grown from pluripotent stem cells combined with single-cell genomic technologies provide opportunities to explore gene regulatory networks (GRNs) underlying human brain development. Here we acquire single-cell transcriptome and accessible chromatin profiling data over a dense time course covering multiple phases of organoid development including neuroepithelial formation, pattern...

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Literature Corpus work: 0a7110e0-9768-54ff-9c45-3d23d928e82d
DOI: 10.1101/2021.08.24.457460

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