Article

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor state

2026-08-24

Abstract excerpt

The mammalian cerebral cortex is built from a conserved developmental program, yet exhibits profound species-specific complexity. To decode the regulatory changes driving human brain evolution, we reconstructed and aligned continuous single-cell differentiation trajectories across the developing human, macaque, mouse, and ferret cortices. This comparative framework revealed a fundamental principle of transcriptomi...

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Literature Corpus work: 8c55b9fa-b1f1-5c4a-b444-0de894d11a78
DOI: 10.64898/2026.08.19.745872

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