Article

Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer’s disease model mice

2026-03-18

Abstract excerpt

<h4>Background</h4> The hallmark lesions of the Alzheimer’s disease (AD) brain are amyloid plaques consisting of the β-amyloid protein and neurofibrillary tangles comprised of hyperphosphorylated, aggregated tau protein, which both cause neuronal dysfunction and loss. One goal of neuroprotective therapies is to maintain normal neuronal function and survival in the presence of toxic pathologies such as plaques and...

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Literature Corpus work: 73f06d89-92a8-51d3-92e3-683362152018
DOI: 10.64898/2026.03.16.711596

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