Article

RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in Alzheimer’s disease

2020-01-02

Abstract excerpt

<title>Abstract</title> <p>Background: Excessive neuronal activity promotes amyloid-β (Aβ) production in the brain. The Aβ oligomer triggers synaptic degeneration that precedes plaque and tangle pathology. However, the signaling molecules that link Aβ oligomers to synaptic pathology remain unclear. RAPGEF2, a guanine-nucleotide exchange factor for the small GTPase Rap, plays a role in activity-dependent synapse r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b83ff18-fd81-5344-8e98-d041e5c58ab4
DOI: 10.21203/rs.2.19961/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in Alzheimer’s diseaseDOI 10.21203/rs.2.19961/v1Read

Suppression of neuronal eEF2K alleviates cognitive deficits and apathy-like behavior in APP/PS1 AD model miceSemantic proximity Read

Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's diseaseSemantic proximity Read

Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal modelSemantic proximity Read

Non-microglial downregulation of <i>PLCG2</i> impairs synaptic function and elicits Alzheimer disease-related hallmarksSemantic proximity Read

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s diseaseSemantic proximity Read

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s mouse modelSemantic proximity Read

Neurotrophic Factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer’s Disease miceSemantic proximity Read

Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model miceSemantic proximity Read

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s diseaseSemantic proximity Read

Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer’s diseaseSemantic proximity Read

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairmentSemantic proximity Read

Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer’s disease model miceSemantic proximity Read