Article

Brain Dicer1 is down-regulated in a mouse model of Alzheimer’s disease via Aβ42-induced repression of nuclear factor erythroid 2-related factor 2

2020-05-07

Abstract excerpt

<title>Abstract</title> <p>Background Oxidative stress critically underlies the neurodegenerative pathogenesis of Alzheimer's disease (AD). Depletion of Dicer1, an endoribonuclease central to microRNA maturation, also leads to neurodegeneration. We therefore hypothesized that altered Dicer1 expression may play a role in AD. Results Using immunoblotting and quantitative real-time PCR, we found that Dicer1 protein...

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Literature Corpus work: 75eaf81e-16b3-58bc-92c4-844a79e8becc
DOI: 10.21203/rs.3.rs-25902/v1

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